Residual Tissue Repository Program Accomplishments & Publications

Revised August, 2009

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Program Accomplishments

Residual Tissue Repository (RTR) program accomplishments to date include publications based on tissue microarrays (TMAs) from breast, colorectal, and pancreatic tumors. From a subset of incident colorectal cancer cases recorded in the Hawaii registry for 1995 (n=286/603; 47%), Hernandez et al. observed that cytokeratins 20 and 7 were over-expressed in malignant versus histologically normal tissue. The TMA cases were similar to non-TMA cases with respect to age, gender, race/ethnicity, anatomic site and survival, but differed from all cases in the population with respect to stage and treatment.

In another reported study, Takikita et al. utilized RTR specimens from the Iowa, Hawaii, and Los Angeles county registries to create a population-based, pancreatic cancer TMA from 161/13,650 recorded cases (1.2%), with over-representation of African-American (12% vs. 9%) and Asian-Pacific Islander (40% vs. 14%) cases compared to the registry populations at large. Multiple core samples were obtained from malignant epithelial and benign normal tissues for each case. Candidate biomarkers were analyzed with respect to survival time from diagnosis to death, using multivariable Cox proportional hazard regression models. Tumor mucin expression (MUC1, MUC2 and MUC5AC) was found to be associated with shorter survival time, even after adjusting for gender, age, race, stage of disease, pancreatic origin versus metastatic site, and ever versus never surgical or radiation treatment. Histologic features and biomarker patterns differed by race, but the investigators acknowledged that the TMA did not include adequate case numbers from diverse population subgroups to provide robust inferences by race/ethnicity.

Single registries within the SEER RTR program have also developed valuable biospecimens resources. These biospecimens have been used in studies of lung, breast, and hematopoietic cancers. The RTR Committee intends to expand the contribution of this population-based biospecimen resource through collaborative cancer research. In keeping with this objective, current and proposed RTR projects are examining biospecimens from SEER cases with a variety of tumor types including primary central nervous system lymphoma, AIDS/HIV-associated cancers, Burkitt lymphoma, and breast, ovarian, colorectal, hepatocellular, and HPV-related cancers.

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Selected Publications

Altirriba J, Garcia A, Sanchez B, et al. The sole presence of CDK4 is not a solid criterion for discriminating between tumor and healthy pancreatic tissues. Int J Cancer 2012;130:2743-5.

Anderson WF, Luo S, Chatterjee N, Rosenberg PS, Matsuno RK, Goodman MT, Hernandez BY, Reichman M, Dolled-Filhart M, O'Regan R, Garcia-Closas M, Perou CM, Jatoi I, Cartun RW, Sherman ME. Human epidermal growth factor receptor-2 and estrogen receptor expression, a demonstration project using the residual tissue repository of the Surveillance, Epidemiology, and End Results (SEER) Program. Breast Cancer Res Treat 2009;113:189-96.

Bonner MR, Bennett WP, Xiong W, Lan Q, Brownson RC, Harris CC, Field RW, Lubin JH, Alavanja MC. Radon, secondhand smoke, glutathione-S-transferase M1 and lung cancer among women. Int J Cancer 2006;119:1462-7.

Cerhan JR, Natkunam Y, Morton LM, Maurer MJ, Asmann Y, Habermann TM, Vasef MA, Cozen W, Lynch CF, Allmer C, Slager SL, Lossos IS, Chanock SJ, Rothman N, Hartge P, Dogan A, Wang SS. LIM domain only 2 protein expression, LMO2 germline genetic variation, and overall survival in diffuse large B-cell lymphoma in the pre-rituximab era. Leuk Lymphoma 2012;53:1105-12.

Chang CM, Schroeder JC, Huang WY, Dunphy CH, Baric RS, Olshan AF, Dorsey KC, Dent GA, Cerhan JR, Lynch CF, Rothman N, Cantor KP, Blair A. Non-Hodgkin lymphoma (NHL) subtypes defined by common translocations: utility of fluorescence in situ hybridization (FISH) in a case-control study. Leuk Res 2010;34:190-5.

Chang CM, Wang SS, Dave BJ, Jain S, Vasef MA, Weisenburger DD, Cozen W, Davis S, Severson RK, Lynch CF, Rothman N, Cerhan JR, Hartge P, Morton LM. Risk factors for non-Hodgkin lymphoma subtypes defined by histology and t(14;18) in a population-based case-control study. Int J Cancer 2011;129:938-47.

Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E, Jiang B, Goodman MT, Sibug-Saber M, Cozen W, Liu L, Lynch CF, Wentzensen N, Jordan RC, Altekruse S, Anderson WF, Rosenberg PS, Gillison ML. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol 2011;29:4294-301.

Esser AK, Miller MR, Huang Q, Meier MM, Beltran-Valero de Bernabé D, Stipp CS, Campbell KP, Lynch CF, Smith BJ, Cohen MB, Henry MD. Loss of LARGE2 disrupts functional glycosylation of alpha-dystroglycan in prostate cancer. J Biol Chem 2013;288:2132-42.

Gargano JW, Wilkinson EJ, Unger ER, Steinau M, Watson M, Huang Y, Copeland G, Cozen W, Goodman MT, Hopenhayn C, Lynch CF, Hernandez BY, Peters ES, Saber MS, Lyu CW, Sands LA, Saraiya M. Prevalence of human papillomavirus types in invasive vulvar cancers and vulvar intraepithelial neoplasia 3 in the United States before vaccine introduction. J Low Genit Tract Dis 2012;16:471-9.

Goodman MT, Hernandez BY, Hewitt S, Lynch CF, Cote TR, Frierson HF Jr, Moskaluk CA, Killeen JL, Cozen W, Key CR, Clegg L, Reichman M, Hankey BF, Edwards B. Tissues from population-based cancer registries: a novel approach to increasing research potential. Hum Pathol 2005 Jul;36(7):812-20.

Hernandez BY, Frierson HF, Moskaluk CA, Li YJ, Clegg L, Cote TR, McCusker ME, Hankey BF, Edwards BK, Goodman MT. CK20 and CK7 protein expression in colorectal cancer: Demonstration of the utility of a population-based tissue microarray. Hum Pathol 2005 Mar;36(3):275-81.

Iakovlev V, Siegel ER, Tsao MS, Haun RS. Expression of kallikrein-related peptidase 7 predicts poor prognosis in patients with unresectable pancreatic ductal adenocarcinoma. Cancer Epidemiol Biomarkers Prev 2012;21:1135-42.

Kwee SA, Hernandez B, Chan O, Wong L. Choline kinase alpha and hexokinase-2 protein expression in hepatocellular carcinoma: association with survival. PLoS One 2012;7:e46591.

Lal G, Hashimi S, Smith BJ, Lynch CF, Zhang L, Robinson RA, Weigel RJ. Extracellular matrix 1 (ECM1) expression is a novel prognostic marker for poor long-term survival in breast cancer: a Hospital-based Cohort Study in Iowa. Ann Surg Oncol 2009;16:2280-7.

Maskarinec G, Erber E, Verheus M, Hernandez BY, Killeen J, Cashin S, Cline JM. Soy consumption and histopathologic markers in breast tissue using tissue microarrays. Nutrition and Cancer-an International Journal 2009;61:708-716.

Matsuno RK, Sherman ME, Visvanathan K, Goodman MT, Hernandez BY, Lynch CF, Ioffe OB, Horio D, Platz C, Altekruse SF, Pfeiffer RM, Anderson WF. Agreement for tumor grade of ovarian carcinoma: analysis of archival tissues from the surveillance, epidemiology, and end results residual tissue repository. Cancer Causes Control 2013;24:749-57.

Mbulaiteye SM PS, Nathwani BN, Weiss LM, Rao N, Emmanuel B, Lynch CF, Hernandez B, Neppalli V, Hawes D, Cockburn MG, Kim A, Williams M, Altekruse S, Bhatia K, Goodman MT, Cozen W. Epstein-Barr virus patterns in U.S. Burkitt lymphoma tumors from the SEER Residual Tissue Repository during 1979-2009. APMIS 2013;121:Epub ahead of print.

Morton LM, Kim CJ, Weiss LM, Bhatia K, Cockburn M, Hawes D, Wang SS, Chang C, Altekruse SF, Engels EA, Cozen W. Molecular characteristics of diffuse large B-cell lymphoma in HIV-infected and HIV-uninfected patients in the pre-HAART and pre-rituximab era. Leuk Lymphoma. 2013 Jun 17. [Epub ahead of print]

Samadder NJ, Vierkant RA, Tillmans LS, Wang AH, Lynch CF, Anderson KE, French AJ, Haile RW, Harnack LJ, Potter JD, Slager SL, Smyrk TC, Thibodeau SN, Cerhan JR, Limburg PJ. Cigarette smoking and colorectal cancer risk by KRAS mutation status among older women. American Journal of Gastroenterology 2012;107:782-789.

Sethi S, Ali-Fehmi R, Franceschi S, Struijk L, van Doorn LJ, Quint W, Albashiti B, Ibrahim M, Kato I. Characteristics and survival of head and neck cancer by HPV status: a cancer registry-based study. Int J Cancer 2012;131:1179-86.

Song MA, Tiirikainen M, Kwee S, Okimoto G, Yu H, Wong LL. Elucidating the landscape of aberrant DNA methylation in hepatocellular carcinoma. PLoS One. 2013;8(2):e55761. Epub 2013 Feb 20.

Steinau M, Unger ER, Hernandez BY, Goodman MT, Copeland G, Hopenhayn C, Cozen W, Saber MS, Huang Y, Peters ES, Lynch CF, Wilkinson EJ, Rajeevan MS, Lyu C, Saraiya M. Human papillomavirus prevalence in invasive anal Cancers in the United States before vaccine introduction. J Low Genit Tract Dis. 2013 Apr 19. [Epub ahead of print]

Sy MS, Altekruse SF, Li C, Lynch CF, Goodman MT, Hernandez BY, Zhou L, Saber MS, Hewitt SM, Xin W. Association of prion protein expression with pancreatic adenocarcinoma survival in the SEER residual tissue repository. Cancer Biomark 2011;10:251-8.

Takikita M, Altekruse S, Lynch CF, Goodman MT, Hernandez BY, Green M, Cozen W, Cockburn M, Saber MS, Topor M, Zeruto C, Abedi-Ardekani B, Reichman ME, Hewitt SM. Associations between selected biomarkers and prognosis in a population-based pancreatic cancer tissue microarray. Cancer Res 2009 Apr 1;69(7):2950-55.

Verheus M, Maskarinec G, Erber E, Steude JS, Killeen J, Hernandez BY, Cline JM. Mammographic density and epithelial histopathologic markers. BMC Cancer 2009;9:182.

Wu AH, Siegmund KD, Long TI, Cozen W, Wan P, Tseng CC, Shibata D, Laird PW. Hormone therapy, DNA methylation and colon cancer. Carcinogenesis 2010;31:1060-1067.

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