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Produced: 03/04/2026 2:30 AM
Question 20240020
Inquiry Details
References:
Subject matter expert
Question:
Histology/Behavior: There are currently no codes available on the ICD-10-CM casefinding list for several of the site-specific intraepithelial neoplasias (8077/2). Will there be an update with additional codes for these sites that currently do not have codes to enable casefinding for these? See the table below.
|
Description |
|
ICD-10 |
|
Anal intraepithelial neoplasia (AIN) |
II or III |
R85.613 |
|
Biliary intraepithelial neoplasia |
High grade |
|
|
Endometrioid (endometrial) intraepithelial neoplasia |
II or Iii |
N85.02 |
|
Esophageal intraepithelial neoplasia |
High grade |
|
|
Glandular intraepithelial neoplasia |
High grade |
|
|
Laryngeal intraepithelial neoplasia |
II or III |
|
|
Lobular intraepithelial neoplasia (LIN) |
II or III |
|
|
Pancreatic intraepithelial neoplasia (PanIN) |
II or III |
|
|
Penile intraepithelial neoplasia (PeIN) |
II or III |
|
|
Squamous intraepithelial neoplasia (excluding cervix) |
II or III |
|
|
Vaginal intraepithelial neoplasia (VAIN) |
II or III |
N89.3 |
|
Vulvar intraepithelial neoplasia (VIN) |
II or III |
N90.3 |
Discussion:
Answer:
Many of these terms are not specified in the codes and definitions in ICD-10-CM. This is because ICD-10-CM does not have the same granularity as ICD-O-3.2. There are a few sites where intraepithelial neoplasia II and/or III are mentioned.
Even though ICD-O-3.2 classifies these as /2 (in-situ), for the intraepithelial neoplasia that are listed in ICD-10-CM, Grade II is designated as benign, while Grade III is designated as in-situ. It is not clear if medical coding will change the Grade II to an in-situ code.
All the in-situ codes (except cervix) are included in the casefinding list. Grade III is included with the in-situ codes; however, there is no guarantee that medical coders will code them as in situ. High grades are coded as in-situ in ICD-10-CM.
For those where there is no specific intraepithelial neoplasia code, the benign codes will cover any benign lesion for that site. This would make for a lot of review using the codes for casefinding. Most of the benign codes were removed from the casefinding list a couple of years ago to make it more manageable.
Use the casefinding list as a guide for these neoplasias. It is not the most definitive source due to the lack of specificity of ICD-10-CM. It is not possible to map every single histology to a specific code. It is also not known how medical coders across the U.S. are coding these neoplasias. For that reason, pathology should remain the foremost casefinding resource used.
The casefinding team will need to review the prepared list below and determine what codes to add. Any updates will be incorporated in the FY2025 updates (October 2024.)
|
Description |
ICD-10-CM Description |
ICD-10-CM Code |
|
Anal intraepithelial neoplasia (AIN II) |
Anal intraepithelial neoplasia I and II (histologically confirmed) |
K62.82 |
|
Anal intraepithelial neoplasia (AIN III) |
Carcinoma of in situ of anus and anal canal |
D01.3 |
|
Biliary intraepithelial neoplasia (high grade) |
Carcinoma in situ of liver, gallbladder and bile ducts |
D01.5 |
|
Endometrioid (endometrial) intraepithelial neoplasia II -Not specified in ICD-10-CM as |
Endometrial intraepithelial neoplasia (EIN) |
N85.02 |
|
Endometrioid (endometrial) intraepithelial neoplasia III -Not specified in ICD-10-CM |
Carcinoma in situ of endometrium |
D07.1 |
|
Esophageal intraepithelial neoplasia (high grade) -Not specified in ICD-10-CM |
Carcinoma in situ of esophagus |
D00.1 |
|
Glandular intraepithelial neoplasia (high grade) -Not specified in ICD-10-CM |
In situ code No specific site or code-could apply to any site |
D00-D09 |
|
Laryngeal intraepithelial neoplasia II I -Not specified in ICD-10-CM |
Other diseases of larynx |
J38.7 |
|
Laryngeal intraepithelial neoplasia III -Not specified in ICD-10-CM |
Carcinoma in situ of larynx |
D02.0 |
|
Lobular intraepithelial neoplasia (LIN) II -No specification of II in ICD-10-CM |
Other benign mammary dysplasia |
N60.8- |
|
Lobular intraepithelial neoplasia (LIN) III --No specification of III in ICD-10-CM |
Carcinoma in situ of breast |
D05.-- |
|
Pancreatic intraepithelial neoplasm II -Not specified in ICD-10-CM |
Benign neoplasm of pancreas |
D13.6 |
|
Pancreatic intraepithelial neoplasm III -Not specified in ICD-10-CM |
Carcinoma in situ of other specified digestive organs (includes pancreas) |
D01.7 |
|
Penile intraepithelial neoplasia (PeIN) II -Not specified in ICD-10-CM |
Benign neoplasm of penis |
D29.0 |
|
Penile intraepithelial neoplasia (PeIN) III -Not specified in ICD-10-CM |
Carcinoma in situ of penis |
D07.4 |
|
Prostatic intraepithelial neoplasia (PIN), III |
Carcinoma in situ of prostate, Prostatic intraepithelial neoplasia [PIN], grade III |
D07.5 |
|
Squamous intraepithelial neoplasia (excluding cervix) II -Not specified in ICD-10-CM |
Benign code -No specific site or code-could apply to any site |
D10-D36 |
|
Squamous intraepithelial neoplasia (excluding cervix) -Not specified in ICD-10-CM |
In situ code No specific site or code-could apply to any site |
D00-D09 |
|
Vaginal intraepithelial neoplasia (VAIN), II |
Moderate vaginal dysplasia -Vaginal intraepithelial neoplasia [VAIN], grade II |
N89.1 |
|
Vaginal intraepithelial neoplasia (VAIN), III |
Carcinoma in situ of vagina -Vaginal intraepithelial neoplasia [VAIN], grade III |
D07.2 |
|
Vulvar intraepithelial neoplasia (VIN), II |
Moderate vulvar dysplasia -Vulvar intraepithelial neoplasia [VIN], grade II |
N90.1 |
|
Vulvar intraepithelial neoplasia (VIN), III |
Carcinoma in situ of vulva -Vulvar intraepithelial neoplasia [VIN], grade III |
D07.1 |
