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Question: 20130079 Status
Final

References
Source 1:   2012 Heme & Lymph Manual & DB
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Source 2:  
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Question
Reportability--Heme & Lymphoid Neoplasms: Are plasma cell dyscrasia & Multiple Myeloma synonyms? Is plasma cell dyscrasia reportable? See discussion.

Discussion
Bone Marrow Biopsy & aspirate state: Plasma cell dyscrasia with IgG kappa expression with FISH (+) for the following abnormalities: 3 copies of 1q21 (25/30 plasma cells) and an extra CCND1 signal (25/34 plasma cells) which is indicative of the presence of other chromosome 11 abnormalities possibly trisomy 11, a change known to occur in plasma cell neoplasms. Flow cytometry: A monoclonal plasma cell population is present, co-expressing cIgG, cKappa, CD56, & CD117 (up to 14% of analyzed cells

Answer
This is not a reportable case. Plasma cell dyscrasia and multiple myeloma are not synonymous terms.

Plasma cell dyscrasia (PCD) is not reportable. PCD is a diverse group of neoplastic diseases that produce a serum M component (monoclonol immunoglobin).

Usually these patients have a plasma cell morphology such as multiple myeloma or heavy chain disease. However, the registrar cannot diagnose multiple myeloma or heavy chain disease (or any other plasma cell neoplasm). There must be a physician statement and/or a positive biopsy.

History


Last Updated
06/21/2013

Date Finalized
07/11/2013