This manual and the corresponding database are to be used for coding cases diagnosed January 1, 2010 and forward. The changes made do not require registrars to recode old cases.

Support Resources

This site provides data collection rules for hematopoietic and lymphoid neoplasms for 2010+. There are two tools for use with these rules:

  1. Hematopoietic & Lymphoid Neoplasm Database (Heme DB)
    1. A tool to assist in screening for reportable cases and determining reportability requirements
    2. The database contains abstracting and coding information for all hematopoietic and lymphoid neoplasm (9590/3-9993/3)
  2. Hematopoietic & Lymphoid Neoplasm Coding Manual (PDF, 3.6 MB)
    1. Reportability instructions and rules for determining the number of primaries, the primary site and histology, and the cell lineage or phenotype
    2. The introduction to the manual has an updated Steps in Priority Order for using the Hematopoietic and Lymphoid Neoplasm Coding Manual & Database.

Please note: The stand-alone version of the Hematopoietic database is no longer provided. The web-based tool provides the most up-to-date information.

Suggested Citation

Ruhl J, Callaghan C, Janes T, Adams S (November 2025). Hematopoietic and Lymphoid Neoplasm Coding Manual. National Cancer Institute, Bethesda, MD, 2025.

The rules, guidelines, and the Hematopoietic Database follow the current edition of the World Health Organization (WHO).
World Health Organization (WHO) Classification of Tumours. Editorial Board. Haematolymphoid tumours. Lyon (France). International Agency for Research on Cancer: 2024. (WHO classification of tumours series, 5th ed.; vol 11) https:://publications.iarc.who.int/637